Kaley Cuoco's The Flight Attendant won't be taking off this time around. 

The acclaimed HBO series, which starred Cuoco as flight attendant Cassie Bowden, has been canceled after two seasons.

"What started out as an attention-grabbing book cover quickly evolved into an extraordinary flight of a lifetime," Cuoco said of the show's ending in a statement to E! News Jan. 19. "I always envisioned TFA as a limited series and thanks to an incredible creative team, we were able to deliver two thrilling seasons.

Of course, hanging up her Imperial Atlantic uniform will be bittersweet.

"Personally, playing Cassie has been a dream come true," she noted, "and I am so grateful for everyone who played a part in bringing this extremely original series to life."

The comedy-thriller's creator, Steve Yockey, reflected on the show's legacy in his own statement. "The Flight Attendant was a true passion project and the reception from viewers and critics alike was pretty stunning," the screenwriter said. "Our unorthodox spectacle of a show really found people."

Yockey concluded his note by assuring fans that the TV drama won't be forgotten, saying, "As we all move on to new projects, those two seasons of television and the incredible team of professionals behind them will always stay at the top of my list."

Based on the 2018 Chris Bohjalian novel of the same name, The Flight Attendant premiered in 2019 and marked Cuoco's first major TV credit since The Big Bang Theory went out with a, er, bang that same year after a whopping 12 seasons. The role went on to earn the 38-year-old three Emmy nods and two Golden Globe nominations. 

Playing such a dark role in The Flight Attendant wasn't always easy for Cuoco, who especially struggled with the character while going through her 2022 divorce from equestrian Karl Cook during the shooting of season two.

"It was one of the hardest years of my life," Cuoco told Variety in August 2022. "Not only personally, but doing this character that was so tormented... I developed a stress rash that ran all the way down my body for three straight months that wouldn't go away. I literally, like, had fire on my leg for three months. I could barely walk."

Thankfully, the cast and on-set crew all rallied around the actress. "One month in, I had an intervention on myself in my trailer—all my producers were in there," Cuoco recalled. "And I said, 'I need help.' It was interesting to say that out loud. And to have everyone be like, 'Yes, we want to help!'"

Worried some of your other favorite shows won't be coming back this year? Keep reading for all the latest TV show cancellations and renewals.  

Star Kaley Cuoco confirmed the HBO show will not be getting a season three. "Personally, playing Cassie has been a dream come true," she said in a Jan. 19 statement, "and I am so grateful for everyone who played a part in bringing this extremely original series to life."

Larry David's Emmy-winning comedy returns for its 12th and final season Feb. 4.

Peacock’s high-octane action-comedy starring Anthony Mackie has been renewed for a second season.

The NBC drama will be back for season two in 2024.

The NBC drama will be back for season two in 2024.

After 14 seasons, the cop drama starring Tom Selleck, Bridget Moynahan and Donnie Wahlberg is ending on CBS in 2024.

The Peacock reality competition series has been renewed for seasons six and seven.

“It’s a dream come true for us to jump back into the world of Unstable," father-son duo Rob Lowe and John Owen Lowe told Tudum.com. "Here’s to season two and the many hours of family therapy that we will need along the way.”

CBS' The Big Bang Theory prequel will end after its upcoming 7th season.The series finale will air May 16.

The FX series about Ryan Reynolds and Rob McElhenney's soccer club Wrexham A.F.C. will be back for season three in 2024.

Jimmy Fallon's musical NBC game show is returning for a third season.

Peacock's dark comedy starring Kaley Cuoco and Chris Messina is returning for season two.

“iCarly will not be returning for a fourth season on Paramount+," the streamer announced Oct. 4. "The series had a great three-season run and delivered on what fans really wanted to see with Carly and Freddie finally getting together.  We want to thank the entire cast, the writers, directors and producers along with the whole crew for their dedication, creativity and talent.”

"Only Murders in the Building is coming back for Season 4!" Hulu announced in October. "Let the investigating begin... "

The ABC comedy will not return after season three, Variety reported.

ABC cancelled the revival of the classic '90s series after two seasons, THR reported.

Hulu has cancelled the comedy after two seasons.

Hulu has cancelled the Elle Fanning, Nicholas Hoult-starring series after three seasons.

OWN announced the courtroom drama's third season will be its last with the final 10 episodes airing fall 2023.

Both RuPaul's Drag Race and RuPaul's Drag Race: All Stars are returning for seasons 16 and nine respectively.

The Hulu docu-series returns for season four Sept. 28.

Tarek El Moussa and Heather Rae El Moussa's HGTV docu-series has been renewed for a second season.

Max announced the Sex and the City revival will be back for season three next year.

The Walking Dead spinoff is returning for season two, AMC announced at Comic-Con 2023.

The Walking Dead spinoff is returning for season two, AMC announced at Comic-Con 2023.

Rose Byrne's dark comedy returns to Apple TV+ for its third and final season Aug. 2.

Katy Perry, Luke Bryan and Lionel Richie will all be returning as judges for the ABC singing competition's upcoming 22nd season.

Bravo's Summer House spinoff Martha's Vineyard, featuring an all-Black cast of friends, has been renewed for season two.

HBO's Emmy-winning comedy series—created, written and starring Robin Thede—will end with its fourth season later this year.

Netflix's coming-of-age comedy returns for its fourth and finale season Sept. 21.

For the latest breaking news updates, click here to download the E! News App